EXCRETION AND RE-EXCRETION OF A BROAD-SPECTRUM PENICILLIN IN BILE

Fecal Bile Excretion

Epidemiological studies have shown a positive association between cholesterol gallstones and colonic cancer. These two diseases may be somehow related with bile acids metabolic alterations. The aim of this study was to evaluate the profiles of fecal bile acid in gallstone patients, in order to estimate the quality and amount of fecal bile acids. A fecal bile acid profile of ten gallstone patien...

The Absorption, Excretion, and Distribution of Penicillin.

Bile pigment excretion: a comparison of the biliary excretion of bilirubin and bilirubin derivatives.

During the process of hepatic excretion, a diverse group of exogenous organic compounds and endogenous metabolites is conjugated with polar anionic molecules (1). Although it is clear that the physical and chemical characteristics of these compounds can be drastically altered by conjugation, the relationship between conjugation and excretion has not been fully elucidated (2). Formation of the g...

Cell volume and bile acid excretion.

The interaction between cell volume and taurocholate excretion into bile was studied in isolated perfused rat liver. Cell swelling due to hypo-osmotic exposure, addition of amino acids or insulin stimulated taurocholate excretion into bile and bile flow, whereas hyperosmotic cell shrinkage inhibited these. These effects were explained by changes in Vmax of taurocholate excretion into bile: Vmax...

Chylomicrons enhance endotoxin excretion in bile.

Chylomicrons prevent endotoxin toxicity and increase endotoxin uptake by hepatocytes. As a consequence, less endotoxin is available to activate macrophages, thereby reducing tumor necrosis factor secretion. To determine whether the chylomicron-mediated increase in hepatocellular uptake of endotoxin results in increased endotoxin excretion into bile, we examined bile after endotoxin administrati...